BCM Department of Medicine

Visit the Chief of Thrombosis Research

PAUL F. BRAY, M.D.

Professor of Medicine, Baylor College of Medicine
Director, Fondren Vascular Biology Laboratory

Contact Information:
One Baylor Plaza
BCM 286, Room N1319
Houston, TX 77030
Phone: (713) 798-3480
Fax: (713) 798-3415
E-mail: pbray@bcm.tmc.edu

Professional Background:

Internship and Residency, Baylor College of Medicine, Houston, Texas, 1977-80
Fellow in Hematology/Oncology, University of California, San Francisco, (UCSF) 1982-85
Postdoctoral Fellow in Thrombosis Research, UCSF, 1985-86
Instructor, Department of Medicine, Hematology/Oncology, UCSF 1986-88
Assistant Professor, Department of Medicine, Hematology/Oncology Division, UCSF, 1988-90
Assistant Professor, Department of Medicine, Hematology Division, Johns Hopkins University, 1990-94
Associate Professor, Departments of Medicine and Pathology, Hematology Division, Johns Hopkins University, 1995-99
Medical Director, Special Coagulation Laboratory, Johns Hopkins Hospital, 1995-99
Chief, Thrombosis Research Section, Baylor College of Medicine, 2000 -
Investigator, Woman's Health Initiative, 2000 -
Professor of Medicine, Baylor College of Medicine, 2001 -
Professor of Pediatrics, Baylor College of Medicine, 2002 -

Research Interests:

(1) The role of platelets in coronary artery thrombosis
(2) Studies on gender differences in platelet function and thrombosis
(3) Studies on the prothrombotic nature of the platelet Fc receptor (FcgRIIa)
(4) Clinical epidemiology studies of patients with arterial thrombotic syndromes (MI, stroke, PAD) focusing on platelet hyperreactivity
(5) Molecular genetics of the inherited bleeding disorder, Glanzmann thrombasthenia using state-of-the-art techniques to detect mutations in the integrin aIIb and b3 genes.

Awards, Honors and Committees:

NIH Physician Scientist Award
American Society of Hematology Subcommittee on Thrombosis
Established Investigatorship, Am. Heart Association
National Blood Foundation Scholar
1997 Cicarone Center Honoree
American Society of Hematology Subcommittee on Platelets
Heme-1 Study Section, National Institutes of Health

Selected Publications (from 60):

(1) Edwards CQ, Carrol M, Bray P, Cartwright GE. Hereditary hemochromatosis: Diagnosis in siblings and children. N Engl J Med 297:7-13, 1977.

(2) Bray PF, Rosa J-P, Lingappa VR, Kan YW, McEver RP, Shuman MA. Biogenesis of the platelet receptor for fibrinogen: Evidence for separate precursors for glycoproteins IIb and IIIa. Proc Natl Acad Sci USA 83: 1480-1484, 1986.

(3) Bray PF, Rosa J-P, Johnston GI, Shiu DT, Cook R, Lau C, Kan YW, McEver RP, Shuman MA. Platelet glycoprotein IIb: chromosomal localization and tissue expression. J Clin Invest 80:1812-1817, 1987.

(4) Rosa J-P, Bray PF, Gayet O, Johnston GI, Cook R, Jackson KW, Shuman MA, McEver RP. Cloning of glycoprotein IIIa from human erythroleukemia cells and localization of the gene to chromosome 17. Blood 72: 593-600, 1988.

(5) Bray PF, Barsh G, Rosa J-P, Luo XY, Magenis E, Shuman MA. Physical linkage of the genes for platelet membrane glycoprotein IIb and IIIa. Proc Natl Acad Sci USA 85:8683-8687, 1988.

(6) Bray PF and Shuman MA. Identification of an abnormal gene for the GPIIIa subunit of the platelet fibrinogen receptor resulting in Glanzmann thrombasthenia. Blood 75: 881-888, 1990.

(7) Bray PF, Leung S-I, Shuman MA. Human platelets and megakaryocytes contain alternately spliced glycoprotein IIb mRNAs. J Biol Chem 265: 9587-9590, 1990.

(8) Li L and Bray PF. Homologous recombination among 3 intragene Alu sequences causes an inversion-deletion resulting in the hereditary bleeding disorder Glanzmann thrombasthenia. Am J Hum Genet 53:140-149, 1993.

(9) Villa-Garcia M, Li L, Riely G, Bray PF. Isolation and characterization of a TATA-less promoter for the human b3 integrin gene. Blood 83:668-676, 1994.

(10) Farady N, Goldschmidt-Clermont P, Dise K, Bray PF. Quantitation of soluble fibrinogen binding to platelets by fluorescence activated flow cytometry. J Lab Clin Med 123:728-740, 1994.

(11) Bray PF, Jin Y, Kickler T. Rapid genotyping of the five major platelet alloantigens by reverse dot blot hybridization. Blood 84:4361-4367, 1994.

(12) Wilhide CC, Dang CV, Dipersio J, Kenedy AA, Bray PF. Over expression of cyclin D1 in the Dami megakaryocytic cell line causes growth arrest. Blood 86:294-304, 1995.

(13) Kim H, Jin Y, Kickler TS, Blakemore K, Kwon OH, Bray PF. Gene frequencies of the five major human platelet antigens in African American, white, and Korean populations. Transfusion 35:863-867, 1995.

(14) Weiss EJ, Bray PF, Tayback M, Schulman SP, Kickler TS, Becker LC, Weiss JL, Gerstenblith G, Goldschmidt-Clermont PJ. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med 334:1090-1094, 1996.

(15) Goldschmidt-Clermont PJ, Schulman SP, Bray PF, Chandra NC, Grigoryev D, et al. Refining the treatment of women with unstable angina a randomized, double-blind, comparative safety and efficacy evaluation of IntegrilinTM versus aspirin in the management of unstable angina. Clin Cardiol 19:869-874, 1996.

(16) Jin Y, Dietz HC, Montgomery R, Bell WR, McIntosh I, Coller B, Bray PF. Glanzmann Thrombasthenia: cooperation between sequence variants in cis during splice site selection. J Clin Invest 98:1745-1754, 1996.

(17) Faraday N, Goldschmidt-Clermont P, Bray PF. Gender differences in platelet GPIIb-IIIa activation. Thromb Haemost 77:748-754, 1997.

(18) Cooke GE, Bray PF, Hamlington J, Pham DM, Goldschmidt-Clermont PJ. PlA2 polymorphism and efficacy of aspirin. Lancet 351:1353, 1998.

(19) Yu DR, Bray PF. Through Thick and Thin (Clinical Problem-Solving case of hemorrhage and thrombosis). N Engl J Med 338:1684-1687, 1998.

(20) Jin Y, Wilhide CC, Li S-X, Li L, Villa-Garcia M, Dang CV, Bray PF. Human integrin b3 gene expression: evidence for a megakaryocytic cell-specific cis-acting element Blood 92:2777-2790, 1998.

(21) Pabla R, Weyrich AS, Dixon DA, Bray PF, McIntyre TM, Prescott SM, Zimmerman GA. Integrin-dependent control of translation: engagement of integrin aIIbb3 regulates synthesis of proteins in activated human platelets. J Cell Biol 144:175-184, 1999.

(22) Michelson AD, Furman MI, Goldschmidt-Clermont P, Mascelli MA, Hendrix C, Coleman L, Hamlington J, Barnard MR, Kickler T, Christie DJ, Kundu S, Bray PF. Platelet GPIIIa PlA polymorphisms display different sensitivity to agonists and antagonists. Circulation 101:1013, 2000.

(23) Vijayan KV, Goldschmidt-Clermont PJ, Roos C, Bray PF. The PlA2 polymorphism of integrin b3 enhaces outside-in signaling and adhesive functions. J Clin Invest 105:793-802, 2000.

(24) Khetawat G, Faraday N, Nealen M, Bolton E, Noga S, Bray PF. Human megakaryocytes and platelets contain the estrogen receptor b and androgen receptor (AR): testosterone regulates AR expression. Blood 95:2289-2296, 2000.

(25) Bray PF. Platelet glycoprotein polymorphisms as risk factors for thrombosis. Curr Opin Hemat 7:284-289, 2000.

Email: medicine@bcm.tmc.edu
URL: http://public.bcm.tmc.edu/medicine/chief.htm (Modified: June 17, 2003)